ZuriNOS 100
Nosiheptide 10%
Thiopeptide antibiotic with potent activity against Gram-positive intestinal bacteria and necrotic enteritis.
About ZuriNOS 100
ZuriNOS 100 provides nosiheptide at 100 g per kg, a thiopeptide antibiotic with a unique macrocyclic structure. Nosiheptide is bactericidal against Gram-positive intestinal pathogens including Clostridium perfringens.
Why choose ZuriNOS 100
Unique Thiopeptide Chemistry
Nosiheptide belongs to the thiopeptide class with no known cross-resistance to any therapeutic antibiotic.
Bactericidal Activity
Nosiheptide is bactericidal against C. perfringens, providing more complete clearance.
NE Prevention
Consistently prevents necrotic enteritis under high Clostridium challenge.
Minimal Absorption
Poor gut absorption minimises systemic exposure and residues.
Staphylococci Coverage
Additional activity against Staphylococcus species provides broader Gram-positive gut protection.
Resistance Reserve
The unique thiopeptide binding mechanism preserves nosiheptide's efficacy as a long-term tool.
How ZuriNOS 100 works
EF-Tu Binding
Nosiheptide binds to elongation factor Tu (EF-Tu) in complex with the ribosome.
GTPase Inhibition
Binding prevents GTP hydrolysis by EF-Tu, blocking aminoacyl-tRNA delivery to the ribosomal A-site.
Bactericidal Action
Complete protein synthesis block results in bactericidal activity against C. perfringens.
Luminal Activity
Poor gut absorption ensures the bactericidal effect is concentrated in the intestinal lumen.
Recommended dosage & use
Always follow veterinary guidance. The dosages below are standard recommendations; higher doses may be advised during disease challenges or deficiency conditions.
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